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Metformin, one of the medicines in SYNJARDY and SYNJARDY XR,. may develop joint pain that can be severe. Call your doctor if you have severe joint pain.Amaryl M S.R. should not exceed the daily doses of glimepiride or metformin already being taken. When switching from combination therapy of glimepiride plus.Metformin improves endothelial vascular reactivity in first-degree relatives of type 2 diabetic patients with metabolic syndrome and normal glucose tolerance.
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